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Current Edition

December 2016

Volume 2 Issue 2

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Case Report

Histiocytic Sarcoma with Simultaneous Gene Rearrangements of both the Clonal Immunoglobulin Heavy Chain and the T-cell Receptor

Kazuya Sato*, Nodoka Tsukada, Junki Inamura, Motohiro Shindo, Satoshi Ito, Masayuki Kon, Keisuke Sato, Takaaki Hosoki

A 77-year-old man was admitted with thrombocytopenia and splenic tumors. Severe thrombocytopenia continued even after high-dose methylprednisolone and intravenous gamma-globulin treatment. Bone marrow (BM) aspiration revealed atypical macrophages and gene rearrangements of both the IgH and TCR. Chemo/radiotherapies were ineffective, then he died from the disease progression. The autopsy revealed proliferation of large neoplastic cells in the spleen, liver and BM. The cells were positive for histiocytic markers, and negative for B-cell and T-cell markers. He was diagnosed with histiocytic sarcoma (HS). This is the first report of sporadic HS with gene rearrangements of both the IgH and TCR.

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Clinical Study

Proven Invasive Fungal Infection during the Pre-Engraftment Period in Pediatric Allogeneic Hematopoietic Stem Cell Transplantation for Non-Malignant Disorders

Abdalla Khalil*, Juma Natsheh, Polina Stepensky, Aharon Gefen, Ronit Leiba, Myriam Ben-Arush, Irina Zaidman

Invasive fungal infection remains a significant cause of morbidity and mortality, particularly during the pre-engraftment neutropenic period, in pediatric allogeneic hematopoietic stem cell transplantation. We retrospectively analyzed epidemiology, incidence, and outcome of IFI in children with non-malignant diseases undergoing HSCT during the preengraftment period. Between 2004 and 2014, 236 patients underwent HSCT for non-malignant disorders at Rambam Health Care Campus in Haifa and Hadassah Hebrew University Medical Center in Jerusalem. Main diagnoses were thalassemia and severe immunodeficiency.

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Research Article

The Effect of Storage on Various Haematological and Biochemical Parameters of NHSBT Donor Blood

Peter Ella-tongwiis, Stephen Fôn Hughes*

Recent studies have reported that blood stored for longer periods (>14days) are associated with the development of post-transfusion complications. Most changes taking place in stored blood are biochemical, biomechanical and haematological and are known as storage lesion. The aim of this study was to investigate the effects of storage on the various haematological and biochemical parameters of National Health Service Blood and Transplant (NHSBT), whole donor blood.

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Research Article

Anticoagulant Treatment after VTE in the Netherlands: A Retrospective Cohort Study

Irene D Bezemer*, Elsa J van den Berg, Ron M C Herings, Luke Bamber, Fernie J A Penning-van Beest, Kerstin Folkerts, Michiel Coppens

Deep vein thrombosis (DVT) and its potentially fatal acute complication, pulmonary embolism (PE), are both manifestations of the same disease process of venous thromboembolism (VTE). Each year, approximately 1-3 per 1000 individuals present with acute symptomatic VTE. However, incidence estimates are highly influenced by study design, data collection and differences in healthcare settings between countries.

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