Volume 1 Issue 4
Treosulfan and Radiation-Induced Cytotoxicity in Myeloid Cell Lines and Primary MDS Cells
Dae Young Zang, Zaneta Holman, Mario A Marcondes, H Joachim Deeg*
Treosulfan, combined with fludarabine is used clinically to condition patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) for hematopoietic cell transplantation. Preliminary data suggest that the addition of low dose total body irradiation (TBI) to that regimen reduces relapse incidence. We determined, in vitro, whether treosulfan enhanced the effect of radiation.
Age and Sex Distribution of Leukemia in Patients Seen at a Tertiary Hospital in Ghana
Ekem*, Dei-Adomakoh YA
The leukemias are malignant proliferations of blood cells and occur worldwide. Although various aetiological agents have been implicated in its development, in any individual case the cause is in most cases unknown. Aetiological agents include ionizing radiation which has been implicated in all except CLL; non-ionizing radiation as in electromagnetic fields, benzene exposure, herbicides, pesticides, fertilizers, diesel fuel and exhaust, infectious agents associated with live stock, Epstein-Barr (E-B) virus, human T-lymphotrophic virus type I (HTLV-I) and human immunodeficiency virus (HIV).