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May 2015

Volume 1  Issue 1 

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Editorial
Collaboration of Hematology and Surgery

Atilla Senayli*

Multidisciplinary evaluations of the diseases can be vital to treatment success. During the emerging treatments course of the hematologic diseases, surgical approaches have become increasingly important. Nowadays, there is a solid integrity between hematology and surgery.

 

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Editorial
Gray Zone Lymphoma: Diagnosis and Treatment

Maher Salamoon*

Gray zone lymphoma is a disease at the interface of Hodgkin’s and Non-Hodgkin’s lymphomas. Considerable progress has been made regarding the origin of the neoplastic cell in classical Hodgkin’s disease, the Reed-Sternberg cell. Recent studies show it is a B cell in almost all cases. However, both clinical and biologic overlap should occur if Hodgkin’s disease is derived from an altered B lymphocyte.

 

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Editorial
A Look at Today’s Classical Hodgkin’s Lymphoma

Mihaila RG*

The existence of Reed Sternberg cells in a reactive inflammatory environment defines the classic type of this malignant lymph proliferation. Its incidence is about 5/100,000 inhabi -tants/year, represents about 1% of cancer cases that occur annually, and is dependent of gender, age, geographic location, ethnic group and socioeconomic status. The highest rates of mortality due to its can be found in countries where the incidence of classic Hodgkin’s lymphoma is the lowest and vice versa.This type of lymphoma has a particular histology, meaning that few lymphoma cells (less than 1% of the lymph node cell population) are surrounded by numerous inflammatory cells.

 

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Editorial

Art Therapy Can Help Detect The Feelings Of Children With Leukemia

Daniela Caprino*, Luisa M. Massimo

Art therapy is becoming part of the care for children in hospital for severe disease, be it cancer or a chronic condition. Expressions of sick children are revealed in their art, mostly in drawings and other handicrafts. They provide a way for adults to know how they are experiencing their world inside the hospital, the relationship with their families and with the staff, pain, anxiety, nostalgia, dreams, and wishes. The language of children is unsophisticated and can be understood through their drawings. Children use symbols and images to represent elements in circumstances they are trying to understand. The purpose of this chapter is to show how art can be the easiest way for sick children to communicate, and how it can become their own therapeutic agent through a self-healing mechanism.

 

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Case Report 

Fatal and Forgotten: Acute Hemolytic Anemia and Renal Failure as a Complication of Transurethral resection of the prostate

Madhav Desai*, Danielle Zimmerman, Anup Kasi Loknath Kumar

 The Transurethral resection of the prostate (TURP) is the most common and widely used procedure for treatment of symptomatic benign hypertrophy of the prostate (BPH). TURP related hyponatremia is a well-known but infrequently encountered problem caused by scrupulous use of bladder irrigants. Acute intravascular hemolysis is a rare catastrophic complication of TURP with scant representation in the medical literature. We report a case of acute intravascular hemolysis due to hypo-osmolality following TURP that led to acute renal failure to the extent of requiring temporary dialysis. We also aim to conduct a review of the literature and discuss strategies to minimize hematologic complications secondary to TURP.

 

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Editorial

The Antiphospholipid Syndrome

Cacciola Rossella*, Gentilini Cacciola Elio, Cacciola Emma

The antiphospholipid syndrome (APS) is an autoimmune thrombophilic condition characterized by the presence in blood of antibodies that recognize phospholipid-binding proteins. The clinical manifestation of APS include arterial and venous thromboembolic events and/or obstetric complications (especially recurrent fetal losses). The antiphospholipid antibodies (aPLA) associated with the disease include the lupus anticoagulant (LA), anti-cardiolipin (a-CL), and anti-β2glycoprotein-I (a-β2GP-I). APS and aPLA can occur in isolation (primary) or in association with systemic lupus erythematosus (secondary).

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Short Communication

Long non-coding RNAs in acute lymphoblastic leukemia

Araceli Diez-Fraile, Eva Terras, Yves Benoit, Tim Lammens*

Recently, it has become apparent that in addition to gene transcription, much of the genome is transcribed into non-coding RNAs (ncRNAs). These ncRNAs have been organized into classes based on length and/or function. The most recently established class includes ncRNAs that are more than 200 nucleotides in length (lncRNAs), and deep-sequencing studies have revealed that the human genome encodes similar numbers of lncRNAs and coding RNAs.

 

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Review Article

D-dimer Levels Among Pregnant Women of African Descent Attending Antenatal Clinic in a Tertiary Hospital in Sokoto, North Western Nigeria

Udomah FP, Isah IZ, Hassan M, John RT, Erhabor O*, Abdulrahaman Y, Isha’q ZI, Buhari H,Ibrahim K, Okwesili A, Onuigwe FU, Ibrahim A, Marafa A

Monitoring of coagulation status in pregnancy is crucial to ensure effective haemostatic management, goal-directed therapy, improved outcomes and successful delivery. D-dimer values are thought to predict prothrombotic states of an individual and there exist an association between hypercoagulability markers like D-dimer and increased risk of coronary events. In this study we evaluated the D- dimer levels among pregnant women of African descent in Sokoto, North Western Nigeria.

 

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Case Report

Pulmonary Thromboembolism as a Manifestation of Paraneoplastic Disease in a Patient with Subclinical Hairy Cell Leukemia, a Challenge in Diagnosis and Treatment of Cancer

Habib Nourani Khojasteh*

Thromboembolism in cancers is more common in advanced diseases and less common as an occult and in early phase of disease. Incidence of vascular thromboembolism is increased seven-fold when compared with non-cancer patients. There is evidence that patients who developed thrombosis three months prior to or shortly after their diagnosis of cancer have poor prognosis. In addition to venous thrombosis, arterial occlusion with stroke and anginal symptoms are relatively common among cancer patients and are possibly related to genetic predisposition.

 

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Short Report

Evaluation of Lymphocyte Subpopulations and Antiphospholipid Antibodies in Patients with Paroxysmal Nocturnal Hemoglobinuria

Francesco Dragoni*, Maria Stefania De Propris, Anna Paola Iori, Sara Raponi, Giovanni Torelli, Maria Gabriella Mazzucconi, Anna Guarini, Robin Foa

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder of hematopoietic cells characterized by the triad of hemolytic anemia, high risk of venous thrombosis and cytopenias. This is a result of the expansion of a stem cell clone with an acquired mutation in the PIG-A gene, resulting in the defective synthesis of glycosylphosphatidylinositol (GPI) and, therefore, in a deficiency on the surface of circulating blood cells of all GPI-linked proteins. Since two complement inhibitors, CD55 and CD59, are GPI-linked, this results in intravascular complement-mediated lysis of red cells.

 

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